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https://i.guim.co.uk/img/media/30870689524998cf05504937070780748bf9e960/349_76_5959_3575/master/5959.jpg?width=1200&height=630&quality=85&auto=format&fit=crop&overlay-align=bottom,left&overlay-width=100p&overlay-base64=L2ltZy9zdGF0aWMvb3ZlcmxheXMvdGctZGVmYXVsdC5wbmc&s=230822f2b1ec81eb59230064fe706129Appointment of vaccine critic knocks some of world’s biggest drugmakers including Moderna, AstraZeneca and GSK